G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells

G0S2 promotes antiestrogenic and pro-migratory responses in ER+ and ER- breast cancer cells

G0/G1 switch gene 2 (G0S2) is known to inhibit lipolysis by inhibiting adipose triglyceride lipase (ATGL). In this report, we dissect the role of G0S2 in ER+ versus ER- breast cancer. Overexpression of G0S2 in ER- cells increased cell proliferation, while G0S2 overexpression in ER+ cells decreased c...

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Bibliographic Details
Main Authors: Andrea K. Corbet, Emmanuel Bikorimana, Raya I. Boyd, Doha Shokry, Kelly Kries, Ayush Gupta, Anneliese Paton, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Erik R. Nelson, Michael J. Spinella, Ratnakar Singh
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Translational Oncology
Subjects:
G0S2
Breast cancer
Estrogen receptor
Antiestrogen
Epithelial mesenchymal transition
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000621

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http://www.sciencedirect.com/science/article/pii/S1936523323000621

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