Fine-Scale Resolution of Runs of Homozygosity Reveal Patterns of Inbreeding and Substantial Overlap with Recessive Disease Genotypes in Domestic Dogs

Fine-Scale Resolution of Runs of Homozygosity Reveal Patterns of Inbreeding and Substantial Overlap with Recessive Disease Genotypes in Domestic Dogs

Inbreeding leaves distinct genomic traces, most notably long genomic tracts that are identical by descent and completely homozygous. These runs of homozygosity (ROH) can contribute to inbreeding depression if they contain deleterious variants that are fully or partially recessive. Several lines of e...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors: Aaron J. Sams, Adam R. Boyko
Format: Article
Sprog:English
Udgivet: Oxford University Press 2019-01-01
Serier:G3: Genes, Genomes, Genetics
Fag:
inbreeding
inbreeding depression
identity-by-descent
canid
Online adgang:http://g3journal.org/lookup/doi/10.1534/g3.118.200836

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200836

Lignende værker