A novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells

A novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells

Abstract Background Podoplanin (PDPN) is a highly conserved, mucin-type protein specific to the lymphatic system. Overexpression of PDPN is associated with the progression of various solid tumors, and plays an important roles in the tumor microenvironment by regulating the immune system. However, th...

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Bibliografski detalji
Glavni autori: Chunyan Feng, Albert Yu, Zhongfu Wang, Kun Wang, Jiawei Chen, Yaojiong Wu, Ting Deng, Huaqing Chen, Yibo Hou, Shaohua Ma, Xiaoyong Dai, Laiqiang Huang
Format: Članak
Jezik:English
Izdano: BMC 2024-01-01
Serija:Journal of Experimental & Clinical Cancer Research
Teme:
Melanoma
PDPN
CY12-RP2 peptide
EMT
Wnt/β-catenin pathway
Immune activation
Online pristup:https://doi.org/10.1186/s13046-023-02910-y

Internet

https://doi.org/10.1186/s13046-023-02910-y

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