Developmental and maintenance defects in Rett syndrome neurons identified by a new mouse staging system in vitro

Developmental and maintenance defects in Rett syndrome neurons identified by a new mouse staging system in vitro

Rett Syndrome (RTT) is a neurodevelopmental disorder associated with intellectual disability, mainly caused by loss-of-function mutations in the MECP2 gene. RTT brains display decreased neuronal size and dendritic arborisation possibly caused by either a developmental failure or a deficit in the mai...

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Bibliographic Details
Main Authors: Gabriele eBaj, Angela ePatrizio, Alberto eMontalbano, Marina eSciancalepore, Enrico eTongiorgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Dendrites
Dendritic Spines
Rett Syndrome
neurodevelopment
hippocampal neurons
Neuronal morphology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00018/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00018/full

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