Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-type specific functions in melanocytic cells. MITF is essential for the survival of pigmented cells, but whereas high levels of MITF drive melanocyte differentiation, lower levels are required to permit proli...

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Bibliographic Details
Main Authors: Claudia Wellbrock, Sareena Rana, Hugh Paterson, Helen Pickersgill, Thijn Brummelkamp, Richard Marais
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2444043?pdf=render

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http://europepmc.org/articles/PMC2444043?pdf=render

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