Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model

Altered Regulation of Striatal Neuronal N-Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model

N-methyl-D-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival. Studies have shown enhanced extrasynaptic GluN2B-type NMDAR (2B-NMDAR) activity in striatal neurons in the YAC128 mouse model of H...

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Bibliographic Details
Main Authors: Rujun Kang, Liang Wang, Shaun S. Sanders, Kurt Zuo, Michael R. Hayden, Lynn A. Raymond
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Huntington disease (HD)
NMDAR palmitoylation
palmitoyl acyltransferase (PAT)
huntingtin interacting protein 14 (HIP14)
huntingtin interacting protein 14-like (HIP14L)
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2019.00003/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2019.00003/full

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