In Vivo Inhibition of miR-34a Modestly Limits Cardiac Enlargement and Fibrosis in a Mouse Model with Established Type 1 Diabetes-Induced Cardiomyopathy, but Does Not Improve Diastolic Function

In Vivo Inhibition of miR-34a Modestly Limits Cardiac Enlargement and Fibrosis in a Mouse Model with Established Type 1 Diabetes-Induced Cardiomyopathy, but Does Not Improve Diastolic Function

MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology, and we previously reported that inhibition of miR-34a in vivo provided protection in a setting of pressure overload-induced pathological cardiac hypertrophy and dilated cardiomyopathy. Prior work had also sh...

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Bibliographic Details
Main Authors: Bianca C. Bernardo, Gunes S. Yildiz, Helen Kiriazis, Claudia A. Harmawan, Celeste M. K. Tai, Rebecca H. Ritchie, Julie R. McMullen
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
diabetes
microRNA
miR-34a
cardiomyopathy
fibrosis
Online Access:https://www.mdpi.com/2073-4409/11/19/3117

Internet

https://www.mdpi.com/2073-4409/11/19/3117

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