Treatment of experimental autoimmune encephalomyelitis using AAV gene therapy by blocking T cell costimulatory pathways

Treatment of experimental autoimmune encephalomyelitis using AAV gene therapy by blocking T cell costimulatory pathways

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by inflammation and demyelination. Presently, repeated relapses of MS necessitate long-term immune-regulatory therapy. Blocking the CD28-B7 and CD40-CD40L costimulatory pathways is an effective...

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Bibliographic Details
Main Authors: Chen Zhong, Zifeng Chen, Yong Xia, Jun Wu, Feixu Zhang, Cheng Cheng, Xia Wu, Yingping Zhuang, Xiao Xiao
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CTLA4-Ig
CD40-Ig
AAV
EAE
multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000596

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http://www.sciencedirect.com/science/article/pii/S2329050122000596

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