PVT1 signals an androgen-dependent transcriptional repression program in prostate cancer cells and a set of the repressed genes predicts high-risk tumors

PVT1 signals an androgen-dependent transcriptional repression program in prostate cancer cells and a set of the repressed genes predicts high-risk tumors

Abstract Background Androgen receptor (AR) and polycomb repressive complex 2 (PRC2) are known to co-occupy the loci of genes that are downregulated by androgen-stimulus. Long intergenic non-coding RNA (lincRNA) PVT1 is an overexpressed oncogene that is associated with AR in LNCaP prostate cancer cel...

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Bibliographic Details
Main Authors: Alexandre Videira, Felipe C. Beckedorff, Lucas F. daSilva, Sergio Verjovski-Almeida
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cell Communication and Signaling
Subjects:
LincRNA PVT1
Prostate cancer
PVT1 knockdown
Genome-wide transcriptional repression
Tumor suppressor genes
Online Access:https://doi.org/10.1186/s12964-020-00691-x

Internet

https://doi.org/10.1186/s12964-020-00691-x

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