Phospholipase D2 Enhances Epidermal Growth Factor-Induced Akt Activation in EL4 Lymphoma Cells

Phospholipase D2 Enhances Epidermal Growth Factor-Induced Akt Activation in EL4 Lymphoma Cells

Phospholipase D2 (PLD2) generates phosphatidic acid through hydrolysis of phosphatidylcholine. PLD2 has been shown to play a role in enhancing tumorigenesis. The epidermal growth factor receptor (EGFR) can both activate and interact with PLD2. Murine lymphoma EL4 cells lacking endogenous PLD2 presen...

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Bibliographic Details
Main Authors: Manpreet S. Chahal, Daniel J. Brauner, Kathryn E. Meier
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Pharmaceuticals
Subjects:
protein kinase inhibitors
phospholipids metabolism
metastasis
Online Access:http://www.mdpi.com/1424-8247/3/7/2045/

Internet

http://www.mdpi.com/1424-8247/3/7/2045/

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