In vivo Overexpression of Electrogenic Sodium/Bicarbonate Cotransporter (NBCe1) by AAV9 Modifies the Cardiac Action Potential and the QT Interval in Mice

In vivo Overexpression of Electrogenic Sodium/Bicarbonate Cotransporter (NBCe1) by AAV9 Modifies the Cardiac Action Potential and the QT Interval in Mice

Cardiac cells depend on specific sarcolemmal ion transporters to assure the correct intracellular pH regulation. The sodium/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms. In the heart two different NBC isoforms have been described: the electroneutral NBCn1 (1Na+:1HCO3-)...

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Bibliographic Details
Main Authors: Romina A. Di Mattía, Leandro A. Díaz Zegarra, Carlos A. Valverde, Paula G. Blanco, Carolina Jaquenod De Giusti, Enrique L. Portiansky, Ernesto A. Aiello, Alejandro Orlowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
NBCe1
adeno-associated virus (AAV)
ECG
action potential
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.862118/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.862118/full

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