The ribosome modulates folding inside the ribosomal exit tunnel

Wruck et al. investigate the folding of the small zinc-finger domain ADR1a inside and at the vestibule of the ribosomal tunnel, using optical tweezers, single-molecule FRET, and molecular dynamics simulations. They find that the ribosomal tunnel accelerates folding while stabilizing the folded state...

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Bibliographic Details
Main Authors: Florian Wruck, Pengfei Tian, Renuka Kudva, Robert B. Best, Gunnar von Heijne, Sander J. Tans, Alexandros Katranidis
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02055-8