Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR inhibitors

Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR inhibitors

Common sensitizing mutations in epidermal growth factor receptor (cEGFR), including exon 19 deletions (19-Del) and exon 21 L858R substitution, are associated with high sensitivity to EGFR-TKIs in NSCLC patients. The treatment for NSCLC patients with uncommon EGFR (uEGFR) mutations remains a subject...

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Bibliographic Details
Main Authors: Yongkang Bai, Xiang Liu, Limin Zheng, Song Wang, Junli Zhang, Shi Xiong, Pengfei Zhang, Zichen Jiao, Gefei Zhao, Chu Zhou, Jiaohui Pang, Yang Xu, Qiuxiang Ou, Yuan Mao, Louqian Zhang
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Common EGFR
Uncommon EGFR
NSCLC
EGFR-TKI
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000131

Internet

http://www.sciencedirect.com/science/article/pii/S1476558623000131

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