LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization

LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization

Aims: Metabolic switching during heart development contributes to postnatal cardiomyocyte (CM) cell cycle exit and loss of regenerative capacity in the mammalian heart. Metabolic control has potential for developing effective CM proliferation strategies. We sought to determine whether lactate dehydr...

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Bibliographic Details
Main Authors: Yijin Chen, Guangkai Wu, Mengsha Li, Michael Hesse, Yusheng Ma, Wei Chen, Haoxiang Huang, Yu Liu, Wenlong Xu, Yating Tang, Hao Zheng, Chuling Li, Zhongqiu Lin, Guojun Chen, Wangjun Liao, Yulin Liao, Jianping Bin, Yanmei Chen
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Redox Biology
Subjects:
LDHA
Metabolic reprogramming
Cardiomyocyte proliferation
ROS
Macrophage polarization
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172200218X

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http://www.sciencedirect.com/science/article/pii/S221323172200218X

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