FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2‐Mediated Alternative Splicing

FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2‐Mediated Alternative Splicing

Abstract Mesenchymal glioblastoma (GBM) is highly resistant to radio‐and chemotherapy and correlates with worse survival outcomes in GBM patients; however, the underlying mechanism determining the mesenchymal phenotype remains largely unclear. Herein, it is revealed that FBXO7, a substrate‐recogniti...

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Bibliographic Details
Main Authors: Shangbiao Li, Yanwen Chen, Yuxin Xie, Hongchao Zhan, Yu Zeng, Kunlin Zeng, Li Wang, Ziling Zhan, Cuiying Li, Liqian Zhao, Xiaoxia Chen, Yujing Tan, Zhongyong Wang, Junguo Bu, Ye Song, Fan Deng, Aidong Zhou
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
alternative splicing
chemoresistance
FBXO7
glioblastoma
mesenchymal transformation
Online Access:https://doi.org/10.1002/advs.202303561

Internet

https://doi.org/10.1002/advs.202303561

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