Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders

Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders

BackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are abundant in the central nervous system (CNS), playing critical roles in brain function. Antigenicity of nAChRs has been well demonstrated with antibodies to ganglionic AChR subtypes (i.e., subunit α3 of α3β4-nAChR) and muscle AChR aut...

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Main Authors: Maria Pechlivanidou, Aigli G. Vakrakou, Katerina Karagiorgou, Erdem Tüzün, Eleni Karachaliou, Elisabeth Chroni, Theodora Afrantou, Nikolaos Grigoriadis, Christina Argyropoulou, Nikolaos Paschalidis, Elif Şanlı, Aikaterini Tsantila, Maria Dandoulaki, Elpinickie I. Ninou, Paraskevi Zisimopoulou, Renato Mantegazza, Francesca Andreetta, Leon Dudeck, Johann Steiner, Jon Martin Lindstrom, Dimitrios Tzanetakos, Konstantinos Voumvourakis, Sotirios Giannopoulos, Georgios Tsivgoulis, Socrates J. Tzartos, John Tzartos
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
neuronal nicotinic acetylcholine receptor
nAChR subunit α4
autoimmunity
autoimmune encephalitis syndromes
autoimmunity-driven cognitive impairment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1388998/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1388998/full

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