Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages

Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages

Abstract DNA methylation is an epigenetic modification that regulates gene expression and plays an essential role in hematopoiesis. UHRF1 and DNMT1 are both crucial for regulating genome-wide maintenance of DNA methylation. Specifically, it is well known that hypermethylation is crucial characterist...

Full description

Bibliographic Details
Main Authors: Junyoung Park, Yongyang Luo, Jin Woo Park, Song Hyun Kim, Ye Joo Hong, Younghyun Lim, Young-Jin Seo, Jeehyeon Bae, Sang Beom Seo
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40362-8

Internet

https://doi.org/10.1038/s41598-023-40362-8

Similar Items