Linking human cerebral and ocular waste clearance: Insights from tear fluid and ultra-high field MRI

Linking human cerebral and ocular waste clearance: Insights from tear fluid and ultra-high field MRI

Impaired cerebral waste clearance (i.e., glymphatics) is evident in aging and neurodegenerative disorders, such as Alzheimer's disease, where an impaired waste clearance system could be related to the accumulation of pathological proteins (e.g., tau). One marker of impaired cerebral clearance i...

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Bibliographic Details
Main Authors: Merel M. van der Thiel, Nienke van de Sande, Anouk Meeusen, Gerhard S. Drenthen, Alida A. Postma, Rudy M.M.A. Nuijts, Noa van der Knaap, Inez H.G.B. Ramakers, Carroll A.B. Webers, Walter H. Backes, Marlies Gijs, Jacobus F.A. Jansen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neurobiology of Disease
Subjects:
Ocular glymphatic system
Perivascular spaces
Waste clearance
Intraocular pressure
Tear fluid
Ultra-high field MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003322

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http://www.sciencedirect.com/science/article/pii/S0969996124003322

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