Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Abstract Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosphate (ATP) release in purinergic-mediated...

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Bibliographic Details
Main Authors: Gareth W. Price, Christos E. Chadjichristos, Panagiotis Kavvadas, Sydney C. W. Tang, Wai Han Yiu, Colin R. Green, Joe A. Potter, Eleftherios Siamantouras, Paul E. Squires, Claire E. Hills
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cell Communication and Signaling
Subjects:
Chronic kidney disease
Connexins
Hemichannels
ATP
Cell adhesion
Tubular injury
Online Access:http://link.springer.com/article/10.1186/s12964-020-00558-1

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http://link.springer.com/article/10.1186/s12964-020-00558-1

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