Cyclic mechanical load causes global translational arrest in articular chondrocytes: a process which is partially dependent upon PKR phosphorylation

he cellular mechanisms by which articular cartilage responds to load are poorly understood, but such responses may involve regulation at the level of protein translation rather than synthesis of mRNA. We investigated the role of translational control in cyclically (0.5 Hz, 0.1 Hz and 0.05 Hz) and st...

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Detalles Bibliográficos
Main Authors: C Lomas, XD Tang, A Chanalaris, J Saklatvala, TL Vincent
Formato: Artigo
Idioma:English
Publicado: Forum Multimedia Publishing LLC 2011-09-01
Series:European Cells & Materials
Subjects:
Acceso en liña:http://www.ecmjournal.org/journal/papers/vol022/pdf/v022a14.pdf