TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

TpiA is a Key Metabolic Enzyme That Affects Virulence and Resistance to Aminoglycoside Antibiotics through CrcZ in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

ABSTRACT Carbon metabolism plays an essential role in bacterial pathogenesis and susceptibility to antibiotics. In Pseudomonas aeruginosa, Crc, Hfq, and a small RNA, CrcZ, are central regulators of carbon metabolism. By screening mutants of genes involved in carbon metabolism, we found that mutation...

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Bibliographic Details
Main Authors: Yushan Xia, Dan Wang, Xiaolei Pan, Bin Xia, Yuding Weng, Yuqing Long, Huan Ren, Jingyi Zhou, Yongxin Jin, Fang Bai, Zhihui Cheng, Shouguang Jin, Weihui Wu
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
Pseudomonas aeruginosa
antibiotic resistance
carbon catabolite repression
triosephosphate isomerase
virulence
Online Access:https://journals.asm.org/doi/10.1128/mBio.02079-19

Internet

https://journals.asm.org/doi/10.1128/mBio.02079-19

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