Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia

Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia

Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that regulates the activation of immune cells, which is a target for treating inflammation. In this study, Cannabidivarin (CBDV), an active component of Cannabis, was identified as an antagonist of TLR4. In vitro, intrinsic protein...

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Bibliographic Details
Main Authors: Xue Wang, Cong Lin, Siru Wu, Tianshu Zhang, Yibo Wang, Yanfang Jiang, Xiaohui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
Toll-like receptor 4
myeloid differentiation protein 2
cannabidivarin
neuroinflammation
analgesia
pain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.929222/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.929222/full

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