Next-Generation Sequencing Analysis of the Within-Host Genetic Diversity of Influenza A(H1N1)pdm09 Viruses in the Upper and Lower Respiratory Tracts of Patients with Severe Influenza

Next-Generation Sequencing Analysis of the Within-Host Genetic Diversity of Influenza A(H1N1)pdm09 Viruses in the Upper and Lower Respiratory Tracts of Patients with Severe Influenza

The D222G/N substitution in the hemagglutinin (HA) protein of influenza A(H1N1)pdm09 virus has been reported to be associated with disease severity and mortality in numerous previous studies. In the present study, 75% of lower respiratory samples contained heterogeneous influenza populations that ca...

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Main Authors: Ikuyo Takayama, Binh Gia Nguyen, Co Xuan Dao, Thach The Pham, Tuan Quoc Dang, Phuong Thai Truong, Thanh Van Do, Thuy Thi Phuong Pham, Seiichiro Fujisaki, Takato Odagiri, Hideki Hasegawa, Noriko Nakajima
Format: Article
Language:English
Published: American Society for Microbiology 2021-02-01
Series:mSphere
Online Access:https://journals.asm.org/doi/10.1128/mSphere.01043-20

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https://journals.asm.org/doi/10.1128/mSphere.01043-20

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