Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

ABSTRACT Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of cytosolic DNA by cGAS results in synthesis of the endogenous second messenger cGAMP that activates stimulator of interferon genes (STING) in infected cells. Crit...

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Bibliographic Details
Main Authors: Geneviève Pépin, Dominic De Nardo, Christina L. Rootes, Tomalika R. Ullah, Sumaiah S. Al-Asmari, Katherine R. Balka, Hong-Mei Li, Kylie M. Quinn, Fiona Moghaddas, Stephane Chappaz, Benjamin T. Kile, Eric F. Morand, Seth L. Masters, Cameron R. Stewart, Bryan R. G. Williams, Michael P. Gantier
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
connexins
STING
cGAMP
cGAS
Online Access:https://journals.asm.org/doi/10.1128/mBio.03187-19

Internet

https://journals.asm.org/doi/10.1128/mBio.03187-19

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