ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth

ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth

Activation of receptor tyrosine kinase signaling inactivates capicua (CIC), a transcriptional repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic translocation. Although CIC is known to be inactivated by phosphorylation, the mechanisms underlying the cytoplasmic transl...

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Bibliographic Details
Main Authors: Jongmin Park, Guk-Yeol Park, Jongeun Lee, Joonyoung Park, Soeun Kim, Eunjeong Kim, Seung-Yeol Park, Jong Hyuk Yoon, Yoontae Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
CIC
ERK
receptor tyrosine kinase
cytoplasmic translocation
tumor suppressor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1030725/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.1030725/full

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