cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies.

cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies.

The objective of this study was to translate reaction conditions and quality control methods used for production of an astatine-211(211At)-labeled anti-CD45 monoclonal antibody (MAb) conjugate, 211At-BC8-B10, from the laboratory setting to cGMP production. Five separate materials were produced in th...

Full description

Bibliographic Details
Main Authors: Yawen Li, Donald K Hamlin, Ming-Kuan Chyan, Roger Wong, Eric F Dorman, Robert C Emery, Douglas R Woodle, Ronald L Manger, Margaret Nartea, Aimee L Kenoyer, Johnnie J Orozco, Damian J Green, Oliver W Press, Rainer Storb, Brenda M Sandmaier, D Scott Wilbur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6193629?pdf=render

Internet

http://europepmc.org/articles/PMC6193629?pdf=render

Similar Items