Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission

Native CGRP Neuropeptide and Its Stable Analogue SAX, But Not CGRP Peptide Fragments, Inhibit Mucosal HIV-1 Transmission

BackgroundThe vasodilator neuropeptide calcitonin gene-related peptide (CGRP) plays both detrimental and protective roles in different pathologies. CGRP is also an essential component of the neuro-immune dialogue between nociceptors and mucosal immune cells. We previously discovered that CGRP is end...

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Bibliographic Details
Main Authors: Jammy Mariotton, Anette Sams, Emmanuel Cohen, Alexis Sennepin, Gabriel Siracusano, Francesca Sanvito, Lars Edvinsson, Nicolas Barry Delongchamps, Marc Zerbib, Lucia Lopalco, Morgane Bomsel, Yonatan Ganor
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
CGRP
HIV-1
humanized BLT mice
Langerhans cells
SAX
STAT4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.785072/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.785072/full

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