Polygoni multiflori radix exacerbates idiosyncratic inflammatory liver injury through the FXR-SHP pathway and altered pharmacokinetic behavior

Polygoni multiflori radix exacerbates idiosyncratic inflammatory liver injury through the FXR-SHP pathway and altered pharmacokinetic behavior

Polygoni multiflori radix (PM) is a well-known tonic herb. It has been reported that PM could cause idiosyncratic inflammatory liver injury in some individuals. In this study, we investigated the mechanism of PM-induced idiosyncratic inflammatory liver injury in zebrafish and rat models based on pha...

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Bibliographic Details
Main Authors: Guoqin Zhang, Jianhua Sun, Meiqi Liu, Zhixiang Tian, Zicheng Ma, Bingyu Hao, Jintang Ning, Xiaoliang Ren, Meng Wang, Ping Wang, Jiunian Li, Hailin Li, Jian Ni, Yi Liu
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Polygoni multiflori radix
Zebrafish
Liver injury
Inflammatory state
FXR-SHP pathway
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000215

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http://www.sciencedirect.com/science/article/pii/S0753332223000215

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