Polygoni multiflori radix exacerbates idiosyncratic inflammatory liver injury through the FXR-SHP pathway and altered pharmacokinetic behavior

Polygoni multiflori radix exacerbates idiosyncratic inflammatory liver injury through the FXR-SHP pathway and altered pharmacokinetic behavior

Polygoni multiflori radix (PM) is a well-known tonic herb. It has been reported that PM could cause idiosyncratic inflammatory liver injury in some individuals. In this study, we investigated the mechanism of PM-induced idiosyncratic inflammatory liver injury in zebrafish and rat models based on pha...

Full description

Bibliographic Details
Main Authors:	Guoqin Zhang, Jianhua Sun, Meiqi Liu, Zhixiang Tian, Zicheng Ma, Bingyu Hao, Jintang Ning, Xiaoliang Ren, Meng Wang, Ping Wang, Jiunian Li, Hailin Li, Jian Ni, Yi Liu
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Polygoni multiflori radix Zebrafish Liver injury Inflammatory state FXR-SHP pathway Pharmacokinetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332223000215

Similar Items

Screening and identifying hepatotoxic components in Polygoni multiflori radix and Polygoni multiflori radix praeparata
by: Guang-Ping Zhang, et al.
Published: (2019-01-01)

Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata
by: Dan Gao, et al.
Published: (2016-10-01)

Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis
by: Li Kang, et al.
Published: (2022-05-01)

Hepatotoxic metabolites in Polygoni Multiflori Radix— Comparative toxicology in mice
by: Shixiao Wang, et al.
Published: (2022-10-01)

Anti-aging activity of Radix polygoni multiflori preparata in aging mice model induced by D-galactose by bioassay method
by: Jiang Yan Huo, et al.
Published: (2016-03-01)

On-line identification of the chemical constituents of Polygoni Multiflori Radix by UHPLC-Q-ToF MS/MS
by: Xueting Wang, et al.
Published: (2023-04-01)

Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats
by: Wenhao Cheng, et al.
Published: (2022-02-01)

Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori
by: Dan Li, et al.
Published: (2020-11-01)

Quality evaluation of various commercial specifications of Polygoni Multiflori Radix and its dregs by determination of active compounds
by: Liang Zhitao, et al.
Published: (2012-06-01)

Simultaneous Determination of Four Anthraquinones in Polygoni Multiflori Radix with Single Reference Standard by High Performance Liquid Chromatography
by: Hua Yang, et al.
Published: (2015-07-01)

Detection of Emodin Derived Glutathione Adduct in Normal Rats Administered with Large Dosage of Polygoni Multiflori Radix
by: Li-Long Jiang, et al.
Published: (2017-07-01)

Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis
by: Yihang Dai, et al.
Published: (2023-03-01)

Integrating Targeted and Untargeted Metabolomics to Investigate the Processing Chemistry of Polygoni Multiflori Radix
by: Li Liang, et al.
Published: (2018-08-01)

Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins
by: Funan Ning, et al.
Published: (2021-07-01)

Comparative Investigation of Raw and Processed Radix Polygoni Multiflori on the Treatment of Vascular Dementia by Liquid Chromatograph−Mass Spectrometry Based Metabolomic Approach
by: Fengye Wu, et al.
Published: (2022-12-01)

Discrimination of Radix Polygoni Multiflori from different geographical areas by UPLC-QTOF/MS combined with chemometrics
by: Jin-Fa Tang, et al.
Published: (2017-12-01)

High-Throughput Identification of Organic Compounds from Polygoni Multiflori Radix Praeparata (<i>Zhiheshouwu</i>) by UHPLC-Q-Exactive Orbitrap-MS
by: Shaoyun Wang, et al.
Published: (2021-06-01)

Tissue-Specific Analysis of Secondary Metabolites Creates a Reliable Morphological Criterion for Quality Grading of Polygoni Multiflori Radix
by: Li Liang, et al.
Published: (2018-05-01)

Analyze the Effect of Steaming on the Chemical Constituents, Defecation and Liver Injury of Polygonum Multiflorum Radix (Heshouwu) by Multiple Analysis Techniques Combined with Multivariate Statistics
by: Xiaolei Du, et al.
Published: (2022-09-01)

Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury
by: Wei-Song Kong, et al.
Published: (2022-04-01)

<i>Caulis Polygoni Multiflori</i> Accelerates Megakaryopoiesis and Thrombopoiesis via Activating PI3K/Akt and MEK/ERK Signaling Pathways
by: Xin Yang, et al.
Published: (2022-09-01)

Gardenia Iridoid Glucosides Protect Against α-Naphthalene Isothiocya-Nate-Induced Cholestatic Rats Through Activation of the FXR-SHP Signaling Pathway
by: Xu M, et al.
Published: (2023-12-01)

Polygoni Cuspidati Rhizoma et Radix extract attenuates high-fat diet-induced NAFLD in rats: Impact on untargeted serum metabolomics and liver lipidomics
by: Huan Zhang, et al.
Published: (2023-12-01)

Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis
by: Jing Chen, et al.
Published: (2023-05-01)

Idiosyncratic liver injury induced by bolus combination treatment with emodin and 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in rats
by: Dan Li, et al.
Published: (2022-09-01)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging
by: Hung-Yun Lin, et al.
Published: (2022-08-01)

Intratracheal exposure to polyhexamethylene guanidine phosphate disrupts coordinate regulation of FXR-SHP-mediated cholesterol and bile acid homeostasis in mouse liver
by: You-Jin Choi, et al.
Published: (2022-12-01)

Rapid Quality Assessment of Polygoni Multiflori Radix Based on Near-Infrared Spectroscopy
by: Bin Jia, et al.
Published: (2024-01-01)

Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from <i>Polygoni cuspidati</i> Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin?
by: Magdalena Paczkowska-Walendowska, et al.
Published: (2022-09-01)

Hypoglycemic and Antioxidant Properties of Extracts and Fractions from Polygoni Avicularis Herba
by: Kun Zhang, et al.
Published: (2022-05-01)

Structural and Functional Analysis of SHP Promoter and Its Transcriptional Response to FXR in Zn-Induced Changes to Lipid Metabolism
by: Han Gao, et al.
Published: (2022-06-01)

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors
by: Xiaozheng Xu, et al.
Published: (2021-11-01)

The Cell-Specific Role of SHP2 in Regulating Bone Homeostasis and Regeneration Niches
by: Jie Zhang, et al.
Published: (2023-01-01)

Strategy for Leukemia Treatment Targeting SHP-1,2 and SHIP
by: Fang Hao, et al.
Published: (2021-08-01)

Mechanism study of tyrosine phosphatase shp-1 in inhibiting hepatocellular carcinoma progression by regulating the SHP2/GM-CSF pathway in TAMs
by: Qiang Wei, et al.
Published: (2024-04-01)

Physiological Role of Bile Acids Modified by the Gut Microbiome
by: Yoshimitsu Kiriyama, et al.
Published: (2021-12-01)

Loss of small heterodimer partner expression in the liver protects against dyslipidemias⃞
by: Helen B. Hartman, et al.
Published: (2009-02-01)

Rapid Screening Alpha-Glucosidase Inhibitors from Polygoni Vivipari Rhizoma by Multi-Step Matrix Solid-Phase Dispersion, Ultrafiltration and HPLC
by: Haoxiang Li, et al.
Published: (2021-10-01)

Exploratory Quality Control Study for <i>Polygonum multiflorum</i> Thunb. Using Dinuclear Anthraquinones with Potential Hepatotoxicity
by: Huiyu Gao, et al.
Published: (2022-10-01)

Hot Melt Extrusion for Improving the Physicochemical Properties of Polydatin Derived from <i>Polygoni cuspidati</i> Extract; A Solution Recommended for Buccal Applications
by: Magdalena Paczkowska-Walendowska, et al.
Published: (2023-08-01)