Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response.

Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response.

B. anthracis is the causative agent of anthrax. Pathogenesis is primarily mediated through the exotoxins lethal factor and edema factor, which bind protective antigen (PA) to gain entry into the host cell. The current anthrax vaccine (AVA, Biothrax) consists of aluminum-adsorbed cell-free filtrates...

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Bibliographic Details
Main Authors: Ravi V Kolla, Suresh Chintalapati, Mojgan Sabet, Eugenio Santelli, Robert C Liddington, Michael David, Joshua Fierer, Donald Guiney, Robert C Rickert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2001179?pdf=render

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http://europepmc.org/articles/PMC2001179?pdf=render

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