Fatal intracranial haemorrhage in acute promyelocytic leukemia patients with short isoform of PML-RARα: Review of molecular and radiological data

Fatal intracranial haemorrhage in acute promyelocytic leukemia patients with short isoform of PML-RARα: Review of molecular and radiological data

Three major PML-RARα fusion gene transcripts (long [bcr1], variant [bcr2], and short [bcr3]) are currently used in clinical laboratories for the diagnosis and treatment monitoring of APL patients. Despite highly improved outcome, relapse and intracranial haemorrhage that may lead to early death is s...

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Bibliographic Details
Main Authors: Manal Abudawood, Hanan Alorini, Manar A. Samman, Salman M. Bashir, Azizah AlSwayed, Sarah Binhassan, Abdul Ali Peer-Zada
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Saudi Journal of Biological Sciences
Subjects:
Acute promyelocytic leukemia (APL)
PML-RARα isoforms
Molecular remission (MR)
Minimal residual disease (MRD)
Quantitative polymerase chain reaction (qPCR)
Central nervous system (CNS)
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X23001559

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http://www.sciencedirect.com/science/article/pii/S1319562X23001559

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