Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade

Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade

Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus (ZIKV) targets GBM stem cells and prevents death of mice with gliomas. Here, we evaluated the immunological basis of ZIKV...

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Detalles Bibliográficos
Main Authors: Sharmila Nair, Luciano Mazzoccoli, Arijita Jash, Jennifer Govero, Sachendra S. Bais, Tong Hu, Camila R. Fontes-Garfias, Chao Shan, Hideho Okada, Sujan Shresta, Jeremy N. Rich, Pei-Yong Shi, Michael S. Diamond, Milan G. Chheda
Formato: Artigo
Idioma:English
Publicado: American Society for Clinical investigation 2021-01-01
Series:JCI Insight
Subjects:
Immunology
Oncology
Acceso en liña:https://doi.org/10.1172/jci.insight.144619

Internet

https://doi.org/10.1172/jci.insight.144619

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