L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice

L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice

We have reported previously that L-cysteine-derived hydrogen sulfide (H2S) demonstrates a remarkable neuroprotective effect against hypoxia-ischemic (HI) insult in neonatal animals. Here, we assessed some of the mechanisms of this protection as exerted by L-cysteine. Specifically, we examined the ca...

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Bibliographic Details
Main Authors: Xin Zhou, Xili Chu, Danqing Xin, Tingting Li, Xuemei Bai, Jie Qiu, Hongtao Yuan, Dexiang Liu, Dachuan Wang, Zhen Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
H2S
hypoxia-ischemia
M2 microglia
AMPK
complement protein
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00058/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00058/full

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