Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues

Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues

Lipid nanoparticles (LNPs) for delivery of mRNA usually contain ionizable lipid/helper lipid/cholesterol/PEG-lipid in molar ratios of 50:10:38.5:1.5, respectively. These LNPs are rapidly cleared from the circulation following intravenous (i.v.) administration, limiting uptake into other tissues. Her...

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Bibliographic Details
Main Authors: Nisha Chander, Genc Basha, Miffy Hok Yan Cheng, Dominik Witzigmann, Pieter R. Cullis
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lipid nanoparticles
mRNA
helper lipids
hepatocytes
splenocytes
bone marrow
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000955

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http://www.sciencedirect.com/science/article/pii/S2329050123000955

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