Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms

Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms

Secreted amyloid precursor protein alpha (sAPPα) processed from a parent human brain protein, APP, can modulate learning and memory. It has potential for development as a therapy preventing, delaying, or even reversing Alzheimer’s disease. In this study a comprehensive analysis to understand how it...

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Bibliographic Details
Main Authors: Katie Peppercorn, Torsten Kleffmann, Owen Jones, Stephanie Hughes, Warren Tate
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
APP
amyloid beta (A4) precursor protein
sAPPα
human neuron
proteome
transcriptome
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.858524/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.858524/full

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