EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains

EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains

Diacylglycerol kinase (DGK) α, which is activated by Ca2+, contains a recoverin homology (RVH) domain, tandem repeats of two Ca2+-binding EF-hand motifs, two cysteine-rich C1 domains and the catalytic domain. We previously found that a DGKα mutant lacking the RVH domain and EF-hands was constitutive...

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Bibliographic Details
Main Authors: Tatsuya Yamamoto, Hiromichi Sakai, Fumio Sakane
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Diacylglycerol kinase
Calcium
C1 domain
EF-hand
Intra-molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000394

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http://www.sciencedirect.com/science/article/pii/S2211546314000394

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