Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status

Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status

Epithelial-mesenchymal transition (EMT) and immune resistance mediated by Programmed Death-Ligand 1 (PD-L1) upregulation are established drivers of tumor progression. Their bi-directional crosstalk has been proposed to facilitate tumor immunoevasion, yet the impact of immunosuppression and spatial h...

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Bibliographic Details
Main Authors: Carlijn M. Lems, Gerhard A. Burger, Joost B. Beltman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
epithelial-mesenchymal transition (EMT)
PD-L1
immunoevasion
ordinary differential equations
cellular Potts model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219669/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1219669/full

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