MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB

MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation via Coregulating BACE1 and PRKACB

Alzheimer’s disease (AD) is characterized by two landmark pathologies, the overproduction of amyloid-beta peptides (Aβ), predominated by the β-amyloid protein precursor cleaving enzyme 1 (BACE1), and hyperphosphorylation of the microtubule protein, tau, because of an imbalance in a kinase/phosphatas...

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Bibliographic Details
Main Authors: Linlin Wang, Jianghong Liu, Qian Wang, Hailun Jiang, Li Zeng, Zhuorong Li, Rui Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
miR-200a-3p
BACE1
PRKACB
tau protein
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00806/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00806/full

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