Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway

Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway

Microcystin-leucine arginine (MC-LR), an emerging water pollutant, produced by cyanobacteria, has an acute testicular toxicity. However, little is known about the chronic toxic effects of MC-LR exposure on the testis at environmental concentrations and the underlying molecular mechanisms. In this st...

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Bibliographic Details
Main Authors: Haohao Liu, Xin Zeng, Ya Ma, Xinghai Chen, Michael D. Losiewicz, Xingde Du, Zhihui Tian, Shiyu Zhang, Linjia Shi, Huizhen Zhang, Fei Yang
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Microcystin-leucine arginine
BTB damages
Reproductive toxicity
Adherens junction changes
Cytoskeleton rearrangement
Water pollution
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322002949

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http://www.sciencedirect.com/science/article/pii/S0147651322002949

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