A single-molecule view of telomerase regulation at telomeres

Telomerase plays a key role in the immortalization of cancer cells by maintaining telomeres length. Using single-molecule imaging of telomerase RNA molecules in cancer cells, we recently reported novel insights into the role of Cajal bodies in telomerase biogenesis and the regulation of telomerase r...

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Bibliographic Details
Main Authors: Pascal Chartrand, Agnel Sfeir
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2020.1818537