<i>Cupriavidus necator</i>-Produced Polyhydroxybutyrate/Eudragit FS Hybrid Nanoparticles Mitigates Ulcerative Colitis via Colon-Targeted Delivery of Cyclosporine A

<i>Cupriavidus necator</i>-Produced Polyhydroxybutyrate/Eudragit FS Hybrid Nanoparticles Mitigates Ulcerative Colitis via Colon-Targeted Delivery of Cyclosporine A

Polyhydroxybutyrate (PHB) has emerged as a novel material for replacing various plastics used in the medical field. However, its application as a drug-delivery carrier for colitis-targeted delivery has not been explored. In this study, we used biosynthesized PHB combined with Eudragit FS (EFS) and c...

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Bibliographic Details
Main Authors: Juho Lee, Aruzhan Saparbayeva, Shwe Phyu Hlaing, Dongmin Kwak, Hyunwoo Kim, Jihyun Kim, Eun Hee Lee, Jin-Wook Yoo
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
polyhydroxybutyrate
pH-responsive
ulcerative colitis
colitis-targeted drug delivery
sustained release
PHB biosynthesis
Online Access:https://www.mdpi.com/1999-4923/14/12/2811

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https://www.mdpi.com/1999-4923/14/12/2811

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