Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation

Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation

Abstract Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disorder that is the leading cause of dementia. The underlying mechanisms of AD have not yet been completely explored. Neuroinflammation, an inflammatory response mediated by certain mediators, has been exhibited to p...

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Bibliographic Details
Main Authors: Xiang Li, Qingyong Ding, Xinxin Wan, Qilong Wu, Shiqing Ye, Yongliang Lou
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Behavioral and Brain Functions
Subjects:
Alzheimer’s disease
Inflammation
Fecal microbiota transplantation
Intestinal microbiota
Short-chain fatty acids
Microbiota-gut-brain axis
Online Access:https://doi.org/10.1186/s12993-024-00265-8

Internet

https://doi.org/10.1186/s12993-024-00265-8

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