Inhibition of CCCTC Binding Factor-Programmed Cell Death Ligand 1 Axis Suppresses Emergence of Chemoresistance Induced by Gastric Cancer-Derived Mesenchymal Stem Cells

Inhibition of CCCTC Binding Factor-Programmed Cell Death Ligand 1 Axis Suppresses Emergence of Chemoresistance Induced by Gastric Cancer-Derived Mesenchymal Stem Cells

BackgroundGastric cancer (GC) is the third leading cause of cancer-associated deaths worldwide. Stromal cells, especially mesenchymal stem cells (MSCs), play significant roles in the development of therapy resistance depending on their paracrine function. The PD-1/PD-L1 crosstalk between cancer and...

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Bibliographic Details
Main Authors: Qianqian Wang, Chao Huang, Ying Ding, Shaodi Wen, Xin Wang, Shuwei Guo, Qiuzhi Gao, Zhihong Chen, Yuanyuan Zhao, Mei Wang, Bo Shen, Wei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stem cells
gastric cancer
5-FU
paclitaxel
PD-L1
CTCF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.884373/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.884373/full

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