Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in <em>Bordetella pertussis</em> Vaccines

Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in <em>Bordetella pertussis</em> Vaccines

The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from <i>Bordetella pertussis (B. pertussis)</i> bacterial fermentation. As such, there are additional <i>B. pertussis</i> toxins that must be monitored as residuals duri...

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Bibliographic Details
Main Authors: Lisa Szymkowicz, Jeffery Gerard, Benjamin Messham, Wai Wan Vivian Tam, D. Andrew James
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Toxins
Subjects:
<i>Bordetella pertussis</i>
adenylate cyclase toxin
dermonecrotic toxin
tracheal cytotoxin
pertussis toxin
quantitative LC-MS
Online Access:https://www.mdpi.com/2072-6651/13/11/763

Internet

https://www.mdpi.com/2072-6651/13/11/763

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