A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage response

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage response

ABSTRACT An interaction between human papillomavirus 16 (HPV16) E2 and the cellular proteins TopBP1 and BRD4 is required for E2 plasmid segregation function. The E2-TopBP1 interaction promotes increased mitotic E2 protein levels in U2OS and N/Tert-1 cells, as well as in human foreskin keratinocytes...

Full description

Bibliographic Details
Main Authors: Apurva T. Prabhakar, Claire D. James, Aya H. Youssef, Reafa A. Hossain, Ronald D. Hill, Molly L. Bristol, Xu Wang, Aanchal Dubey, Elmira Karimi, Iain M. Morgan
Format: Article
Language:English
Published: American Society for Microbiology 2024-06-01
Series:mBio
Subjects:
papillomavirus
mitosis
chromosome segregation
E2
TopBP1
SIRT1
Online Access:https://journals.asm.org/doi/10.1128/mbio.00676-24

Internet

https://journals.asm.org/doi/10.1128/mbio.00676-24

Similar Items