Notopterol mitigates IL-1β-triggered pyroptosis by blocking NLRP3 inflammasome via the JAK2/NF-kB/hsa-miR-4282 route in osteoarthritis

Notopterol mitigates IL-1β-triggered pyroptosis by blocking NLRP3 inflammasome via the JAK2/NF-kB/hsa-miR-4282 route in osteoarthritis

1. Abstract: Objective: Osteoarthritis (OA), the most prevalent form of arthritis, impacts approximately 10% of men and 18% of women aged above 60 years. Currently, a complete cure for OA remains elusive, making clinical management challenging. The traditional Chinese herb Notopterygium incisum, in...

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Bibliographic Details
Main Authors: Ko-Ta Chen, Chi-Tai Yeh, Vijesh Kumar Yadav, Narpati Wesa Pikatan, Iat-Hang Fong, Wei-Hwa Lee, Yen-Shuo Chiu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Osteoarthritis
Notopterol
Interleukin 1 beta
Pyroptosis
NLRP3 inflammasome
JAK2/NF-κB/hsa-miR-4282 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024041252

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http://www.sciencedirect.com/science/article/pii/S2405844024041252

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