Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice

Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice

Alzheimer's disease (AD) is the most serious neurodegenerative disease worldwide and is characterized by progressive cognitive impairment and multiple neurological changes, including neuronal loss in the brain. However, there are no available drugs to delay or cure this disease. Consequently, n...

Full description

Bibliographic Details
Main Authors: Shao-Heng Li, Peng Gao, Li-Tong Wang, Yu-Hui Yan, Yang Xia, Jie Song, Hong-Yan Li, Jing-Xian Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Neuroscience
Subjects:
osthole
Alzheimer's disease
amyloid precursor protein
neural stem cell
microRNA-9
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00340/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00340/full

Similar Items