Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells

Defining the Role of Nuclear Factor (NF)-κB p105 Subunit in Human Macrophage by Transcriptomic Analysis of NFKB1 Knockout THP1 Cells

Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the status of master regulator of the immune response. Much of what we understand of the role of NF-ĸB in immune development, homeostasis and inflammation comes from studies of mice null for specific NF-ĸB sub...

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Bibliographic Details
Main Authors: Domenico Somma, Fatma O. Kok, David Kerrigan, Christine A. Wells, Ruaidhrí J. Carmody
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
NF-κB
macrophage
NFKB1
transcriptomics
toll-like receptors
THP1 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.669906/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.669906/full

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