Aptamer-iRNAs as Therapeutics for Cancer Treatment

Aptamer-iRNAs as Therapeutics for Cancer Treatment

Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize their targets with high affinity and specificity due to their complex tertiary structure. Aptamers are selected by a method called SELEX (Systematic Evolution of Ligands by EXponential enrichment). This method has...

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Bibliographic Details
Main Authors: Mario M. Soldevilla, Daniel Meraviglia-Crivelli de Caso, Ashwathi P. Menon, Fernando Pastor
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceuticals
Subjects:
aptamer
cancer
iRNA
siRNA
shRNA
microRNA
antagomirs
antisense oligonucleotides
DNA
RNA
therapeutics
Online Access:http://www.mdpi.com/1424-8247/11/4/108

Internet

http://www.mdpi.com/1424-8247/11/4/108

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