Osteostatin Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression

Osteostatin Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression

Gouty arthritis results from monosodium urate (MSU) crystal deposition in joints, initiating (pro)-interleukin (IL)-1β maturation, inflammatory mediator release, and neutrophil infiltration, leading to joint swelling and pain. Parathyroid hormone-related protein (107–111) C-terminal peptide (osteost...

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Bibliographic Details
Main Authors: Laura Catalán, María Carmen Carceller, María Carmen Terencio, María José Alcaraz, María Luisa Ferrándiz, María Carmen Montesinos
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
osteostatin
gouty arthritis
inflammation
caspase-1
immune response
Nrf2
Online Access:https://www.mdpi.com/1422-0067/25/5/2752

Internet

https://www.mdpi.com/1422-0067/25/5/2752

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